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NAFLD
https://www.ncbi.nlm.nih.gov/pubmed/28699612
Shi JQ1, Shen WX, Wang XZ, Huang K, Zou CC. Indian Pediatr. 2017 Jul 11. pii: S097475591600073. [Epub ahead of print]
Abstract
OBJECTIVE:
To investigate the relationship between immune parameters and non-alcoholic fatty liver disease (NAFLD) in obese children.
DESIGN:
Case-control study.
SETTING:
Zhejiang Province, China on July to September 2015.
PARTICIPANTS:
A total of 117 obese children and 209 healthy non-obese children were studied as the obese and control groups. Depending on the severity of NAFLD, the obese group was divided into subgroups 1 (without NAFLD), 2 (with simple fatty liver) and 3 (with steatohepatitis).
MAIN OUTCOME MEASURES:
Glucose metabolism, lipid metabolism and immune parameters.
RESULTS:
https://pubmed.ncbi.nlm.nih.gov/34400208/ NAFLD
J Pediatr. 2021 Aug 13;S0022-3476(21)00768-X.
doi: 10.1016/j.jpeds.2021.08.012.Online ahead of print.
Relationship of Enhanced Liver Fibrosis Score with Pediatric Non-alcoholic Fatty Liver Disease Histology and Response to Vitamin E or Metformin
Samer Gawrieh 1, Kathryn E Harlow 2, Francis Pike 3, Katherine P Yates 4, Laura A Wilson 4, Oscar W Cummings 5, William M Rosenberg 6, Naga Chalasani 7, Jean P Molleston 2
Objectives: To study the diagnostic performance of the enhanced liver fibrosis score (ELF) for detecting different stages of fibrosis and its usefulness in detecting histological response to vitamin E or metformin in children with NAFLD who participated in the TONIC trial.
https://pubmed.ncbi.nlm.nih.gov/33086717/ NAFLD
J Clin Med. 2020 Oct 19;9(10):3355.
doi: 10.3390/jcm9103355.
Relative Skeletal Muscle Mass Is an Important Factor in Non-Alcoholic Fatty Liver Disease in Non-Obese Children and Adolescents
Yoowon Kwon 1, Su Jin Jeong 1
Abstract
https://www.ncbi.nlm.nih.gov/pubmed/32267017 NAFLD
J Clin Lab Anal. 2020 Apr 8:e23285. doi: 10.1002/jcla.23285. [Epub ahead of print]
Revision of serum ALT upper limits of normal facilitates assessment of mild liverinjury in obese children with non-alcoholic fatty liver disease.
Lu Y1,2,3, Wang Q1,2,3, Yu L1,2,3, Yin X1,2,3, Yang H1,2,3, Xu X1,2,3, Xia Y1,2,3, Luo Y4, Peng Y2,3, Yu Q5, Chen Z1, Yu J1, Lai M1, Wu N6, Pan XB7, Zheng X1,2,3.
Abstract
BACKGROUND:
The serum alanine aminotransferase (ALT) level is a critical parameter for evaluating liver injury in non-alcoholic fatty liver disease (NAFLD). However, the currently accepted upper limits of normal (ULN) for serum ALT (ULN-ALT) are debated, as they may be excessively high.
METHODS:
https://www.ncbi.nlm.nih.gov/pubmed/31555572 NAFLD
Pediatr Gastroenterol Hepatol Nutr. 2019 Sep;22(5):470-478. doi: 10.5223/pghn.2019.22.5.470. Epub 2019 Sep 11.
Role of Soluble Adiponectin Receptor 2 in Non-Alcoholic Fatty Liver Disease in Children.
Aksoy GK1, Artan R2, Aksoy C3, Özdem S4, Atalay A2, Yılmaz A2.
Abstract
PURPOSE:
The incidence of non-alcoholic fatty liver disease (NAFLD) in children is gradually increasing. The aim of this study was to investigate the use of serum adiponectin and soluble adiponectin receptor 2 (soluble Adipo R2) levels for the diagnosis of fatty liver disease in obese and overweight children.
METHODS:
https://www.ncbi.nlm.nih.gov/pubmed/28213828
Kummer S, Klee D, Kircheis G, Friedt M, Schaper J, Häussinger D, Mayatepek E, Meissner T.
Eur J Pediatr. 2017 Feb 17. doi: 10.1007/s00431-017-2876-1.
Abstract
http://www.ncbi.nlm.nih.gov/pubmed/25729888
Jahnel J, Zöhrer E, Alisi A, Ferrari F, Ceccarelli S, De Vito R, Scharnagl H, Stojakovic T, Fauler G, Trauner M, Nobili V. Serum Bile Acid Levels in Children With Nonalcoholic Fatty Liver Disease. J Pediatr Gastroenterol Nutr. 2015 Jul;61(1):85-90.
Abstract
OBJECTIVE:
Because the prevalence of obesity in children is increasing, the frequency of pediatric nonalcoholic fatty liver disease(NAFLD) is growing. A reliable noninvasive biomarker for monitoring progression of liver fibrosis would be useful. In cirrhotic personsserum bile acid (BA) levels are significantly elevated. We hypothesized that BA levels and composition in pediatric NAFLD vary depending on the stage of fibrosis.
METHODS:
Puri, Kanika*; Nobili, Valerio§; Melville, Katherine†; Corte, Claudia D.§; Sartorelli, Maria R.§; Lopez, Rocio‡; Feldstein, Ariel E.||; Alkhouri, Naim†
http://journals.lww.com/jpgn/Abstract/2013/07000/Serum_Bilirubin_Level_I...
Abstract
Objectives: Oxidative stress has been implicated in the development of nonalcoholic fatty liver disease (NAFLD) and progression to the more severe form, nonalcoholic steatohepatitis (NASH), in children. We aimed to study the clinical correlation between bilirubin, a potent endogenous antioxidant with cytoprotective properties, and histopathological findings in pediatric patients with NAFLD.
Feldstein AE, Alkhouri N, De Vito R, Alisi A, Lopez R, Nobili V. Serum cytokeratin-18 fragment levels are useful biomarkers for non-alcoholic steatohepatitis in children. Am J Gastroenterol.
Abstract
OBJECTIVES:
J Pediatr Gastroenterol Nutr. 2013 Feb;56(2):145-50. doi: 10.1097/MPG.0b013e3182722aee.
Serum retinol-binding protein 4 is independently associated with pediatric NAFLD and fasting triglyceride level.
Huang SC, Yang YJ.
Source
Department of Pediatrics, Kuo General Hospital, Tainan, Taiwan.
Abstract
OBJECTIVES:
Nonalcoholic fatty liver disease (NAFLD) is identified as a major liver disease in children. The present study aimed to identify the prevalence and predictors of pediatric NAFLD and the correlation between serum retinol-binding protein 4 (RBP4) levels and metabolic characteristics in children.
METHODS:
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