https://www.ncbi.nlm.nih.gov/pubmed/28699612

Shi JQ1, Shen WX, Wang XZ, Huang K, Zou CC. Indian Pediatr. 2017 Jul 11. pii: S097475591600073. [Epub ahead of print]

Abstract

OBJECTIVE:
To investigate the relationship between immune parameters and non-alcoholic fatty liver disease (NAFLD) in obese children.

DESIGN:
Case-control study.

SETTING:
Zhejiang Province, China on July to September 2015.

PARTICIPANTS:
A total of 117 obese children and 209 healthy non-obese children were studied as the obese and control groups. Depending on the severity of NAFLD, the obese group was divided into subgroups 1 (without NAFLD), 2 (with simple fatty liver) and 3 (with steatohepatitis).

MAIN OUTCOME MEASURES:
Glucose metabolism, lipid metabolism and immune parameters.

RESULTS:
In the obese group, body mass index (BMI), waist-and hip-circumferences, fasting insulin, Homeostasis model of assessment for insulin resistance (HOMA-IR), triglyceride, total cholesterol, low density lipoprotein cholesterol (LDL-C), apolipoprotein (Apo)B/ApoA1, alanine aminotransferase, uric acid, white blood cells, neutrophils percentage, platelet and interleukin (IL)-6 were significantly higher than those in the controls (P<0.05), while lower high density lipoprotein cholesterol and lymphocyte percentage were noted (P<0.05). IL-10 in the subgroup 3 was higher than those in the control group, subgroup 1 and 2 (P<0.05). Logistic regression analysis showed that BMI, LDL-C, HOMA-IR and IL-10 were independent factors of NAFLD (P<0.05).

CONCLUSIONS:
These results support a low-grade chronic inflammation in obese children. Moreover, obesity, dyslipidaemia and IR are risk factors while IL-10 may be a protective factor for NAFLD.

Published on: 
Aug-2017

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