NAFLD

ttps://pubmed.ncbi.nlm.nih.gov/34289397/ NAFLD

J Hepatol. 2021 Jul 10;S0168-8278(21)01899-7.
doi: 10.1016/j.jhep.2021.06.045.Online ahead of print.

Maternal obesity increases the risk and severity of NAFLD in offspring
Hannes Hagström 1, Tracey G Simon 2, Bjorn Roelstraete 3, Olof Stephansson 4, Jonas Söderling 5, Jonas F Ludvigsson 6

Abstract
Background and aims: Maternal obesity has been linked to the development of cardiovascular disease and diabetes in offspring, but its relationship to non-alcoholic fatty liver disease (NAFLD) is unclear.

Published on: 
Jul-2021

https://www.ncbi.nlm.nih.gov/pubmed/31255652 NAFLD

Gastroenterology. 2019 Jun 27. pii: S0016-5085(19)41037-8. doi: 10.1053/j.gastro.2019.06.028.
Microbiome Signatures Associated with Steatohepatitis and Moderate to Severe Fibrosis in Children With Nonalcoholic Fatty Liver Disease.

Schwimmer JB1, Johnson JS2, Angeles JE3, Behling C4, Belt PH5, Borecki I6, Bross C7, Durelle J8, Goyal NP9, Hamilton G10, Holtz ML11, Lavine JE12, Mitreva M13, Newton KP14, Pan A15, Simpson PM16, Sirlin CB17, Sodergren E18, Tyagi R19, Yates KP20, Weinstock G21, Salzman NH22.

Abstract

BACKGROUND & AIMS:
The intestinal microbiome might affect development and severity of nonalcoholic fatty liver disease (NAFLD). We analyzed microbiomes of children with and without NAFLD.

METHODS:

Published on: 
Jun-2019

What is NAFLD?

NAFLD i.e. non alcoholic fatty liver disease is a medical condition, in which the fat content of the liver is increased. This causes damage to liver cells and their death. Further, the function of liver is disturbed, and it becomes increasingly stiff or fibrosed (cirrhosis)

Usually, such a degeneration of liver is seen in chronic alcoholics. However, NAFLD constitutes a group of patients who do not consume a significant amount of alcohol, and still exhibit similar changes in liver. Hence the name, non alcoholic fatty liver disease.

https://www.ncbi.nlm.nih.gov/pubmed/30335699 NAFLD

Transplantation. 2018 Oct 31. doi: 10.1097/TP.0000000000002490. [Epub ahead of print]
NAFLD and liver transplantation in children - Working group report from the ILTS single topic conference on NAFLD.
Cananzi M1, Vajro P2, Rela M3, Dhawan A4.

Abstract

BACKGROUND:
NAFLD has now become a common cause of chronic liver disease in children, however unlike adults liver transplantation is rarely required as treatment. It is important that in children presenting with NAFLD, secondary causes of fatty liver particularly inherited metabolic defects should be excluded.

METHODS:

Published on: 
Oct-2018

https://pubmed.ncbi.nlm.nih.gov/33851883/ NAFLD

Expert Rev Gastroenterol Hepatol. 2021 Apr 14;1-10.
doi: 10.1080/17474124.2021.1906649.Online ahead of print.

NAFLD and renal function in children: is there a genetic link?

Anna Di Sessa 1, Stefano Guarino 1, Antonio Paride Passaro 1, Laura Liguori 1, Giuseppina Rosaria Umano 1, Grazia Cirillo 1, Emanuele Miraglia Del Giudice 1, Pierluigi Marzuillo 1

Abstract

Published on: 
Apr-2021

https://www.ncbi.nlm.nih.gov/pubmed/27906803

Vos MB, Abrams SH, Barlow SE, Caprio S, Daniels SR, Kohli R, Mouzaki M, Sathya P, Schwimmer JB, Sundaram SS, Xanthakos SA. J Pediatr Gastroenterol Nutr. 2016 Nov 30.

Abstract

Nonalcoholic fatty liver disease (NAFLD) is a highly prevalent chronic liver disease that occurs in the setting of insulin resistance and increased adiposity. It has rapidly evolved into the most common liver disease seen in the pediatric population and is a management challenge for general pediatric practitioners, subspecialists and for health systems. In this guideline, the expert committee on NAFLD (ECON) reviewed and summarized the available literature, formulating recommendations to guide screening and clinical care of children with NAFLD.

Published on: 
Nov-2016

https://www.ncbi.nlm.nih.gov/pubmed/28107283

Vos MB, Abrams SH, Barlow SE, Caprio S, Daniels SR, Kohli R, Mouzaki M, Sathya P, Schwimmer JB, Sundaram SS, Xanthakos SA. J Pediatr Gastroenterol Nutr. 2017 Feb;64(2):319-334. doi: 10.1097/MPG.0000000000001482.

Abstract

Published on: 
Jan-2017

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