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NAFLD
http://www.ncbi.nlm.nih.gov/pubmed/22467277
Hepatology. 2012 Dec;56(6):2142-53. doi: 10.1002/hep.25742.
Hepatic progenitor cells activation, fibrosis, and adipokines production in pediatric nonalcoholic fatty liver disease.
Nobili V, Carpino G, Alisi A, Franchitto A, Alpini G, De Vito R, Onori P, Alvaro D, Gaudio E.
Source
Unit of Liver Research, Bambino Gesù Children's Hospital, Instituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
Abstract
https://pubmed.ncbi.nlm.nih.gov/33545191/ NAFLD
J Pediatr. 2021 Feb 2;S0022-3476(21)00098-6.
doi: 10.1016/j.jpeds.2021.01.064. Online ahead of print.
Hepatic steatosis is negatively associated with bone mineral density in children
Lauren F Chun 1, Elizabeth L Yu 2, Mary Catherine Sawh 2, Craig Bross 1, Jeanne Nichols 3, Lynda Polgreen 4, Cynthia Knott 5, Alexandra Schlein 6, Claude B Sirlin 6, Michael S Middleton 6, Deborah M Kado 7, Jeffrey B Schwimmer 8
Abstract
Objective: To evaluate the relationship between hepatic steatosis and bone mineral density (BMD) in children. Additionally, to assess 25-hydroxyvitamin D levels in the relationship between hepatic steatosis and BMD.
http://www.ncbi.nlm.nih.gov/pubmed/25079479
Patel KR, White FV, Deutsch GH. Hepatic steatosis is prevalent in stillborns delivered to women with diabetes mellitus. J Pediatr Gastroenterol Nutr. 2015 Feb;60(2): 152-8.
Abstract
OBJECTIVE:
Maternal diabetes is a risk factor for pregnancy complications, including stillbirth and macrosomia. Evolving data suggest that diabetes during pregnancy also has long-term consequences for offspring, putting them at risk for obesity and the metabolic syndrome in childhood. Because nonalcoholic fatty liver disease is known to occur in adults and children with insulin resistance, we hypothesized that altered lipid metabolism in fetuses of diabetic mothers may manifest with hepatic steatosis.
METHODS:
https://www.ncbi.nlm.nih.gov/pubmed/30685742
J Pediatr Endocrinol Metab. 2019 Jan 26. pii: /j/jpem.ahead-of-print/jpem-2018-0255/jpem-2018-0255.xml. doi: 10.1515/jpem-2018-0255. [Epub ahead of print]
Hepatopathies in children and adolescents with type 1 diabetes.
Aydın F1, Gerenli N2, Dursun F3, Atasoy TÖ4, Kalın S4, Kırmızıbekmez H5.
Abstract
https://pubmed.ncbi.nlm.nih.gov/34046333/ NAFLD
Pediatr Gastroenterol Hepatol Nutr. 2021 May;24(3):295-305.
doi: 10.5223/pghn.2021.24.3.295.Epub 2021 May 4.
Hepcidin Levels and Pathological Characteristics in Children with Fatty Liver Disease
Norito Tsutsumi 1, Shigeo Nishimata 1, Masaru Shimura 1 2, Yasuyo Kashiwagi 1, Hisashi Kawashima 1
Abstract
Purpose: Hepcidin levels have previously been reported to be correlated with liver damage. However, the association between hepcidin levels and liver fibrosis in children with fatty liver disease remains unclear. This study therefore aimed to investigate the pathophysiology of fibrosis in children with fatty liver disease and its association with hepcidin levels.
https://pubmed.ncbi.nlm.nih.gov/32767607/ NAFLD
J Paediatr Child Health. 2020 Oct;56(10):1590-1596.
doi: 10.1111/jpc.15038. Epub 2020 Aug 7.
High prevalence of elevated serum liver enzymes in Chinese children suggests metabolic syndrome as a common risk factor
Jinling Wang 1, Hui-Qi Qu 2, Ke Huang 1, Wei Wu 1, Chunlin Wang 3, Li Liang 3, Chunxiu Gong 4, Feng Xiong 5, Feihong Luo 6, Geli Liu 7, Shaoke Chen 8, Lifeng Tian 2, Hakon Hakonarson 2 9, Junfen Fu 1
Abstract
Aim: This study investigated the pattern of liver enzymes in a large cohort of Chinese children and adolescents, including 16 383 individuals aged 4-18 years old recruited at six medical centres in China.
http://www.ncbi.nlm.nih.gov/pubmed/24360992
Molleston JP, Schwimmer JB, Yates KP, Murray KF, Cummings OW, Lavine JE, Brunt
EM, Scheimann AO, Unalp-Arida A; NASH Clinical Research Network. Histological abnormalities in children with nonalcoholic fatty liver disease and normal or mildly elevated alanine aminotransferase levels. J Pediatr. 2014 Apr; 164(4): 707-713.
Abstract
OBJECTIVE:
To investigate the histological spectrum of nonalcoholic fatty liver disease (NAFLD) in children with normal, mildly elevated (26-50 U/L boys, 23-44 U/L girls), or elevated (>50 U/L in boys, >44 U/L in girls) serum alanine aminotransferase (ALT) levels.
STUDY DESIGN:
http://www.ncbi.nlm.nih.gov/pubmed/27569726
Schwimmer JB, Lavine JE, Wilson LA, Neuschwander-Tetri BA, Xanthakos SA, Kohli R, Barlow SE, Vos MB, Karpen SJ, Molleston JP, Whitington PF, Rosenthal P, Jain AK, Murray KF, Brunt EM, Kleiner DE, Van Natta ML, Clark JM, Tonascia J, Doo E; NASH CRN. Gastroenterology. 2016 Aug 25.
Abstract
BACKGROUND & AIMS:
No treatment for nonalcoholic fatty liver disease (NAFLD) has been approved by regulatory agencies. We performed a randomized controlled trial to determine whether 52 weeks of cysteamine bitartrate delayed release (CBDR) reduces the severity of liver disease in children with NAFLD.
METHODS:
https://www.ncbi.nlm.nih.gov/pubmed/27569726
Schwimmer JB, Lavine JE, Wilson LA, Neuschwander-Tetri BA, Xanthakos SA, Kohli R, Barlow SE, Vos MB, Karpen SJ, Molleston JP, Whitington PF, Rosenthal P, Jain AK, Murray KF, Brunt EM, Kleiner DE, Van Natta ML, Clark JM, Tonascia J, Doo E; NASH CRN.
Gastroenterology. 2016 Dec;151(6):1141-1154.e9. doi: 10.1053/j.gastro.2016.08.027.
Abstract
BACKGROUND & AIMS:
No treatment for nonalcoholic fatty liver disease (NAFLD) has been approved by regulatory agencies. We performed a randomized controlled trial to determine whether 52 weeks of cysteamine bitartrate delayed release (CBDR) reduces the severity of liver disease in children with NAFLD.
METHODS:
https://pubmed.ncbi.nlm.nih.gov/35442241/ NAFLD
J Pediatr Gastroenterol Nutr. 2022 Apr 20.
doi: 10.1097/MPG.0000000000003461.Online ahead of print.
Insight into the Adolescent Patient Experience with Nonalcoholic Fatty Liver Disease
Sanita L Ley 1 2, Katherine M Kidwell 1 3, Tori R Van Dyk 4, Sarah Orkin 2 5, Cathleen Odar Stough 6, Taylor Howarth 1, Amy R Goetz 1 7, Stavra A Xanthakos 2 5, Kristin Bramlage 2 4, Marialena Mouzaki 2 5, Ana Catalina Arce-Clachar 2 5, Meg H Zeller 1 2
Abstract
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