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Acute Liver Failure
https://www.ncbi.nlm.nih.gov/pubmed/27496798
Narkewicz MR, Horslen S, Belle SH, Rudnick DA, Ng VL, Rosenthal P, Romero R, Loomes KM, Zhang S, Hardison RM, Squires RH; Pediatric Acute Liver Failure Study Group..
J Pediatr Gastroenterol Nutr. 2017 Feb;64(2):210-217.
Abstract
OBJECTIVES:
The purpose of the present study is to estimate autoantibody (auto-AB) frequency, clinical characteristics, and 21-day outcome of participants in the Pediatric Acute Liver Failure Study Group (PALFSG) by antinuclear antibody, smooth muscle antibody, and liver-kidney microsomal (LKM) antibody status.
METHODS:
Auto-ABs were determined at local and/or central laboratories. Subjects were assigned to autoimmune hepatitis (AIH), indeterminate, and other diagnoses groups.
RESULTS:
http://www.ncbi.nlm.nih.gov/
Helbling D, Buchaklian A, Wang J, Wong LJ, Dimmock D. Reduced mitochondrial
DNA content and heterozygous nuclear gene mutations in patients with acute liver
failure. J Pediatr Gastroenterol Nutr.
https://pubmed.ncbi.nlm.nih.gov/33633079/ Acute Liver Failure
J Pediatr Gastroenterol Nutr. 2021 Feb 24.
doi: 10.1097/MPG.0000000000003108.Online ahead of print.
Safety of High-Volume Plasmapheresis in Children With Acute Liver Failure
Marianne Hørby Jørgensen 1, Allan Rasmussen, Vibeke Brix Christensen, Anne-Mette Bæk Jensen, Lise Fonsmark, Bente Utoft Andreassen, Mette Brimnes Damholt, Fin Stolze Larsen
Abstract
https://www.ncbi.nlm.nih.gov/pubmed/28612320
Shailja Vajpayee, R K Gupta, M L Gupta
Abstract
Neonatal hepatitis with acute liver failure due to varied etiology including various infections is reported in the past. Scrub typhus as a cause of neonatal hepatitis has rarely been reported in literature. A high index of clinical suspicion is required for early diagnosis and timely treatment. Severity and prognosis of the disease varies widely because several different strains of Orientia tsutsugamushi exist with different virulence. Delayed diagnosis can result in complication and significant morbidity and mortality. Here, we report three cases of neonatal hepatitis with acute liver failure caused by scrub typhus to increase awareness.
KEYWORDS:
https://www.ncbi.nlm.nih.gov/pubmed/28045774
Sood V, Rawat D, Khanna R, Sharma S, Gupta PK, Alam S, Sarin SK. J Pediatr Gastroenterol Nutr. 2016 Dec 30. doi: 10.1097/MPG.0000000000001510.
Abstract
OBJECTIVES:
Fatty acid oxidation defects (FAODs) may underlie or modify the course of acute liver failure (ALF). Overall significance of carnitine/acylcarnitine and aminoacid profile in ALF is similarly undetermined. Thus, this study was undertaken to study the abnormalities in carnitine/acylcarnitine and aminoacid profile in ALF.
PATIENTS AND METHODS:
A prospective study was performed including all cases of ALF and detailed evaluation including metabolic testing was done.
RESULTS:
https://www.ncbi.nlm.nih.gov/pubmed/28663066
Di Giorgio A1, Sonzogni A2, Piccichè A3, Alessio G4, Bonanomi E5, Colledan M6, D'Antiga L7.
ABSTRACT
BACKGROUND:
Identifying the causes of acute liver failure (ALF) and predictors of death or liver transplantation (LTX) is crucial to decide its management. We aimed to describe features and outcome of ALF in Italian children.
METHODS:
Retrospective review of cases presenting between 1996-2012. ALF was defined by high transaminases, INR ≥2.0 regardless of hepatic encephalopathy (HE), no evidence of underlying chronic liver disease.
RESULTS:
https://pubmed.ncbi.nlm.nih.gov/35412509/ Acute liver failure
Pediatr Crit Care Med. 2022 Apr 12.
doi: 10.1097/PCC.0000000000002962.Online ahead of print.
Transcranial Doppler Ultrasonography in Children With Acute Liver Failure and Severe Hepatic Encephalopathy
Vladimir L Cousin 1, Ramy Charbel 1, Narjess Ghali 1, Clémence Marais 1, Pierre Tissières 1 2
Abstract
Objectives: To report our single-center use of transcranial Doppler (TCD) for noninvasive neuromonitoring in pediatric patients with acute liver failure (ALF).
Design: Retrospective cohort from January 2016 to June 2019.
Setting: PICU in Bicêtre Hospital, Assistance Publique- Hôpitaux de Paris (AP-HP), a national referral center for pediatric liver transplantation.
https://www.ncbi.nlm.nih.gov/pubmed/31884440 Acute liver failure
Indian Pediatr. 2019 Dec 15;56(12):1055-1056.
Wolcott-Rallison Syndrome- Endocrinopathy with Recurrent Acute Liver Failure.
Valamparampil JJ1, Shanmugam N2, Rela M3.
Abstract
A 2-yr-old child with early onset diabetes and hypothyroidism, and diagnosed as Wolcott-Rallison Syndrome, developed two episodes of acute liver failure and recovered, but he remains at high risk of developing another episode of acute liver failure. Autoimmune, metabolic or genetic disorders should be evaluated in children with recurrent acute liver failure and genetic tests needs to be considered.
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